Hitting Jackpot - 12/10/08

Save the game before you start playing the slot machine. Then, keep reloading your saved game until you hit the jackpot.

Molotov Cocktails - 12/10/08

While normally the various alcoholic beverages (for example, Arcadia Merlot, Old Tom Whiskey, etc.) scattered throughout the game are used to recover health, they can be turned into Molotov cocktails similar to those used by the "Nitro Splicer" enemy. To do this, use a source of flame, such as the chemical thrower, the Incinerate! Plasmid or an environmental source. Ignite the alcohol bottle, pick it up with the Telekinesis Plasmid, and throw it at the enemy of choice.

Hint: Sander Cohen - 12/10/08

About halfway through the game, you meet Sander Cohen, this crazy artist dude. When you finish the level, you can just leave him or kill him. If you kill him at that point, you can't get one of the Achievements "Find Cohen's Room." A while later you will stumble onto Cohen's apartment. If he's alive, two Splicers will be dancing in the main room, with Cohen watching from his locked private room. Kill the Splicers and then Cohen comes out to fight you, thus unlocking the door and allowing you to earn the Achievement.